The ability of different types of fungi to degrade various organic pollutants is well documented, yet ‘bioremediation’ strategies have not come into widespread industrial use or community practice. There is still much to learn about the potential roles fungi can play in remediating contaminated sites and the interplay of different types of organisms to increase the degradation and stabilization of organic and inorganic contaminants, especially in field and real-world conditions containing multiple, complex contaminants. This presentation will explore the opportunities and challenges of applying mycology to complex environmental issues.